What is a clinically important change in the Unified Dyskinesia Rating Scale in Parkinson's disease?
Identifieur interne : 000474 ( Main/Exploration ); précédent : 000473; suivant : 000475What is a clinically important change in the Unified Dyskinesia Rating Scale in Parkinson's disease?
Auteurs : Tiago A. Mestre [Canada] ; Isabelle Beaulieu-Boire [Canada] ; Camila C. Aquino [Canada] ; Nicolas Phielipp [États-Unis] ; Yu Yan Poon [Canada] ; Jane P. Lui [Canada] ; Julie So [Canada] ; Susan H. Fox [Canada]Source :
- Parkinsonism & related disorders [ 1873-5126 ] ; 2015.
English descriptors
- KwdEn :
- Aged, Clinical Trials, Phase II as Topic, Dopamine Agents (administration & dosage), Dopamine Agents (pharmacology), Double-Blind Method, Dyskinesias (drug therapy), Female, Humans, Levodopa (administration & dosage), Levodopa (pharmacology), Male, Middle Aged, Parkinson Disease (drug therapy), Patient Outcome Assessment.
- MESH :
- chemical , administration & dosage : Dopamine Agents, Levodopa.
- chemical , pharmacology : Dopamine Agents, Levodopa.
- drug therapy : Dyskinesias, Parkinson Disease.
- Aged, Clinical Trials, Phase II as Topic, Double-Blind Method, Female, Humans, Male, Middle Aged, Patient Outcome Assessment.
Abstract
Dyskinesia remain a significant problem in Parkinson Disease (PD). The translation process of novel drug targets for dyskinesia has proven difficult with several failures at phase III level. Determining the 'clinically important change' (CIC) for dyskinesia rating scales in phase II clinical trials may assist in optimizing drug development of new anti-dyskinetic treatments. We used a standard phase IIa acute levodopa infusion paradigm to determine for the first time the CIC for dyskinesia using the new UDysRS.
DOI: 10.1016/j.parkreldis.2015.09.044
PubMed: 26439944
Affiliations:
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Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Ontario, Canada; The Parkinson's Disease and Movement Disorder Centre, Division of Neurology, Department of Medicine, The Ottawa Hospital, The Ottawa Hospital Research Institute, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Beaulieu Boire, Isabelle" sort="Beaulieu Boire, Isabelle" uniqKey="Beaulieu Boire I" first="Isabelle" last="Beaulieu-Boire">Isabelle Beaulieu-Boire</name><affiliation wicri:level="1"><nlm:affiliation>Movement Disorders Centre and Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Ontario, Canada; Division of Neurology, Department of Medicine, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Movement Disorders Centre and Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Ontario, Canada; Division of Neurology, Department of Medicine, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Aquino, Camila C" sort="Aquino, Camila C" uniqKey="Aquino C" first="Camila C" last="Aquino">Camila C. 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Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Ontario, Canada; Department of Neurology (Movement Disorders), University of California Irvine, Irvine, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Movement Disorders Centre and Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Ontario, Canada; Department of Neurology (Movement Disorders), University of California Irvine, Irvine, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Poon, Yu Yan" sort="Poon, Yu Yan" uniqKey="Poon Y" first="Yu Yan" last="Poon">Yu Yan Poon</name><affiliation wicri:level="1"><nlm:affiliation>Movement Disorders Centre and Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Movement Disorders Centre and Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Lui, Jane P" sort="Lui, Jane P" uniqKey="Lui J" first="Jane P" last="Lui">Jane P. Lui</name><affiliation wicri:level="1"><nlm:affiliation>Movement Disorders Centre and Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Ontario, Canada; University Health Network, Toronto Western Hospital, Department of Pharmacy, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Movement Disorders Centre and Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Ontario, Canada; University Health Network, Toronto Western Hospital, Department of Pharmacy, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="So, Julie" sort="So, Julie" uniqKey="So J" first="Julie" last="So">Julie So</name><affiliation wicri:level="1"><nlm:affiliation>Movement Disorders Centre and Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Movement Disorders Centre and Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Fox, Susan H" sort="Fox, Susan H" uniqKey="Fox S" first="Susan H" last="Fox">Susan H. Fox</name><affiliation wicri:level="1"><nlm:affiliation>Movement Disorders Centre and Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Movement Disorders Centre and Edmond J. 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Mestre</name><affiliation wicri:level="1"><nlm:affiliation>Movement Disorders Centre and Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Ontario, Canada; The Parkinson's Disease and Movement Disorder Centre, Division of Neurology, Department of Medicine, The Ottawa Hospital, The Ottawa Hospital Research Institute, Ottawa, Ontario, Canada. Electronic address: tmestre@toh.on.ca.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Movement Disorders Centre and Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Ontario, Canada; The Parkinson's Disease and Movement Disorder Centre, Division of Neurology, Department of Medicine, The Ottawa Hospital, The Ottawa Hospital Research Institute, Ottawa, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Beaulieu Boire, Isabelle" sort="Beaulieu Boire, Isabelle" uniqKey="Beaulieu Boire I" first="Isabelle" last="Beaulieu-Boire">Isabelle Beaulieu-Boire</name><affiliation wicri:level="1"><nlm:affiliation>Movement Disorders Centre and Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Ontario, Canada; Division of Neurology, Department of Medicine, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Movement Disorders Centre and Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Ontario, Canada; Division of Neurology, Department of Medicine, Centre Hospitalier Universitaire de Sherbrooke, Université de Sherbrooke, Sherbrooke, Québec</wicri:regionArea><wicri:noRegion>Québec</wicri:noRegion></affiliation></author><author><name sortKey="Aquino, Camila C" sort="Aquino, Camila C" uniqKey="Aquino C" first="Camila C" last="Aquino">Camila C. Aquino</name><affiliation wicri:level="1"><nlm:affiliation>Movement Disorders Centre and Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Movement Disorders Centre and Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Phielipp, Nicolas" sort="Phielipp, Nicolas" uniqKey="Phielipp N" first="Nicolas" last="Phielipp">Nicolas Phielipp</name><affiliation wicri:level="2"><nlm:affiliation>Movement Disorders Centre and Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Ontario, Canada; Department of Neurology (Movement Disorders), University of California Irvine, Irvine, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Movement Disorders Centre and Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Ontario, Canada; Department of Neurology (Movement Disorders), University of California Irvine, Irvine, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Poon, Yu Yan" sort="Poon, Yu Yan" uniqKey="Poon Y" first="Yu Yan" last="Poon">Yu Yan Poon</name><affiliation wicri:level="1"><nlm:affiliation>Movement Disorders Centre and Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Movement Disorders Centre and Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Lui, Jane P" sort="Lui, Jane P" uniqKey="Lui J" first="Jane P" last="Lui">Jane P. Lui</name><affiliation wicri:level="1"><nlm:affiliation>Movement Disorders Centre and Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Ontario, Canada; University Health Network, Toronto Western Hospital, Department of Pharmacy, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Movement Disorders Centre and Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Ontario, Canada; University Health Network, Toronto Western Hospital, Department of Pharmacy, Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="So, Julie" sort="So, Julie" uniqKey="So J" first="Julie" last="So">Julie So</name><affiliation wicri:level="1"><nlm:affiliation>Movement Disorders Centre and Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Movement Disorders Centre and Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Fox, Susan H" sort="Fox, Susan H" uniqKey="Fox S" first="Susan H" last="Fox">Susan H. Fox</name><affiliation wicri:level="1"><nlm:affiliation>Movement Disorders Centre and Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Movement Disorders Centre and Edmond J. Safra Program in Parkinson's Disease, Toronto Western Hospital, University Health Network, Division of Neurology, University of Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author></analytic><series><title level="j">Parkinsonism & related disorders</title><idno type="eISSN">1873-5126</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Clinical Trials, Phase II as Topic</term><term>Dopamine Agents (administration & dosage)</term><term>Dopamine Agents (pharmacology)</term><term>Double-Blind Method</term><term>Dyskinesias (drug therapy)</term><term>Female</term><term>Humans</term><term>Levodopa (administration & dosage)</term><term>Levodopa (pharmacology)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (drug therapy)</term><term>Patient Outcome Assessment</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Dopamine Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Dopamine Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Dyskinesias</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Clinical Trials, Phase II as Topic</term><term>Double-Blind Method</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Patient Outcome Assessment</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Dyskinesia remain a significant problem in Parkinson Disease (PD). The translation process of novel drug targets for dyskinesia has proven difficult with several failures at phase III level. Determining the 'clinically important change' (CIC) for dyskinesia rating scales in phase II clinical trials may assist in optimizing drug development of new anti-dyskinetic treatments. We used a standard phase IIa acute levodopa infusion paradigm to determine for the first time the CIC for dyskinesia using the new UDysRS.</div></front></TEI><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><country name="Canada"><noRegion><name sortKey="Mestre, Tiago A" sort="Mestre, Tiago A" uniqKey="Mestre T" first="Tiago A" last="Mestre">Tiago A. Mestre</name></noRegion><name sortKey="Aquino, Camila C" sort="Aquino, Camila C" uniqKey="Aquino C" first="Camila C" last="Aquino">Camila C. Aquino</name><name sortKey="Beaulieu Boire, Isabelle" sort="Beaulieu Boire, Isabelle" uniqKey="Beaulieu Boire I" first="Isabelle" last="Beaulieu-Boire">Isabelle Beaulieu-Boire</name><name sortKey="Fox, Susan H" sort="Fox, Susan H" uniqKey="Fox S" first="Susan H" last="Fox">Susan H. Fox</name><name sortKey="Lui, Jane P" sort="Lui, Jane P" uniqKey="Lui J" first="Jane P" last="Lui">Jane P. Lui</name><name sortKey="Poon, Yu Yan" sort="Poon, Yu Yan" uniqKey="Poon Y" first="Yu Yan" last="Poon">Yu Yan Poon</name><name sortKey="So, Julie" sort="So, Julie" uniqKey="So J" first="Julie" last="So">Julie So</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Phielipp, Nicolas" sort="Phielipp, Nicolas" uniqKey="Phielipp N" first="Nicolas" last="Phielipp">Nicolas Phielipp</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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